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Coffee with a Founder Podcast: Charlie Silver, Ruby Bio

On today’s episode, Beck Bamberger sits down with Charlie Silver, Co-Founder and CEO of Ruby Bio.

Charlie unpacks the real challenges of bringing biotech innovations to market, the lessons learned from past successes and failures, and why humility and intellectual honesty are crucial in the world of synthetic biology.

show notes:

01:03 - Overhauling the chemicals industry

05:13 - Rethinking the venture approach

08:02 - Learning from past biotech failures

11:03 - Intellectual honesty in business

14:04 - Why this mission matters

17:01 - Methodical co-founder matchmaking

18:04 - Embracing the 0-to-1 phase

Read More About The Episode:

 

01:03 - Overhauling the chemicals industry
Charlie Silver shares Ruby Bio’s bold mission to modernize an industry that has remained essentially unchanged for decades. He highlights the importance of sustainable feedstocks and improved chemical products, demonstrating how foundational yet often overlooked the sector truly is.

05:13 - Rethinking the venture approach
The conversation turns to venture investing. Charlie explains why traditional startup playbooks don’t always fit chemical companies, given the industry’s unique economics, scale, and timelines.

08:02 - Learning from past biotech failures
Charlie highlights the importance of experience in scaling biotech, sharing lessons from ventures that didn’t succeed, and how Ruby Bio avoids the same pitfalls.

11:03 - Intellectual honesty in business
Charlie discusses the “not invented here” mindset in startups and big companies, emphasizing that true innovation often means looking beyond your own technology.

14:04 - Why this mission matters
Charlie reflects on Ruby Bio’s global impact, explaining why innovation in chemicals matters for future generations.

17:01 - Methodical co-founder matchmaking
Charlie describes his careful process of partnering with co-founder Pavan. Before launching Ruby Bio, they spent significant time analyzing market needs and technical viability, ensuring they were ready to build at the right moment.

18:04 - Embracing the 0-to-1 phase
Charlie shares his love for the early, scrappy stage of building a company—prioritizing problems, testing ideas, and learning fast, even with experience in larger organizations.

 

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